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Other brands with the same active ingredient
These brands contain the same active ingredient (Doxophylline). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Clarence Tablet 400 mg is indicated for:
Pharmacology
Doxophylline is a newer type of bronchodilator. Its structure differs from Theophylline's by the presence of a dioxolane group at position 7. It works by selectively blocking the phosphodiesterase 4 enzyme, which relaxes the smooth muscle lining the airways. Unlike Theophylline, however, Doxophylline binds much less strongly to adenosine A1 and A2 receptors, and this is thought to be why it tends to be better tolerated. It has also been shown to suppress platelet-activating factor (PAF) and reduce the production of leukotrienes.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Elderly: one 200 mg tablet two or three times daily.
Adults: one 400 mg tablet two or three times daily, or as prescribed by the physician.
Children above 12 years of age: 10 ml syrup or one 200 mg tablet two or three times daily.
Children aged 6 to 12 years: 6 to 9 mg per kg of body weight twice daily. For example, a child weighing 10 kg would take 3 ml (60 mg) twice daily, or as prescribed by the physician.
If the required daily dose of Doxophylline is 400 mg, the Doxophylline SR tablet may be taken once daily, or as prescribed by the physician.
Side Effects
Patients taking xanthine-derivative medicines such as doxophylline may experience nausea, vomiting, stomach (epigastric) pain, headache, irritability, insomnia, a fast heartbeat, extra heartbeats (extrasystoles), and rapid breathing. Rarely, high blood sugar or protein in the urine can occur. These symptoms can be an early warning sign of toxicity, and taking too much of the medicine may lead to serious heart rhythm disturbances or seizures. If side effects appear, the treatment may need to be stopped. Once all signs of toxicity have cleared, the physician may, if appropriate, restart treatment at a lower dose.
Cautions & Contraindications
Warnings & Precautions
Numerous factors can slow the liver's clearance of xanthine derivatives, causing the drug's plasma levels to rise. These include age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concurrent infections, and the simultaneous use of certain drugs such as erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol. Where these factors are present, a dose reduction may be necessary. Whenever such factors could affect clearance of xanthine derivatives, monitoring the drug's blood concentration is recommended to keep it within the therapeutic range. Caution is advised when giving this medicine to patients with cardiac disease, hypertension, severe hypoxemia, hyperthyroidism, chronic cor pulmonale, congestive heart failure, liver disease, peptic ulcer, or renal impairment, as well as to elderly patients. Particular caution is needed in congestive heart failure, since drug clearance is considerably slower in these patients, and high blood levels may persist for a long time even after treatment is stopped. There is no risk of addiction or any other form of dependence.
Contraindications
Doxophylline should not be used by anyone who is hypersensitive to it or to related xanthine medicines. It is also unsuitable for patients who have recently had a heart attack, those with low blood pressure, and women who are breastfeeding.
Pregnancy & Breastfeeding
In animal tests, the active ingredient of Doxophylline did not interfere with growth before or after birth. There isn't enough clinical evidence yet about how the medicine affects pregnant women, so its use during pregnancy should be weighed carefully case by case, looking at the risk against the benefit.
Doxophylline is contraindicated during breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Doxophylline can cause severe cardiac arrhythmias and tonic-clonic seizures. These may be the first signs of intoxication. If side effects appear, the treatment may have to be stopped. The doctor can then restart it at a lower dose, if needed, once all signs and symptoms of toxicity have gone. There is no specific antidote, so an overdose is managed by treating the symptoms, and cardiovascular collapse should be treated symptomatically.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children. DFN should be used only on prescription of specialist physician.
Drug Interactions
Common questions about Clarence Tablet 400 mg 400 mg
What is Clarence Tablet 400 mg 400 mg Tablet?
Clarence Tablet 400 mg 400 mg Tablet is a medicine that contains Doxophylline. It is made by Healthcare Pharmaceuticals Ltd. It belongs to the Bronchodilator group of medicines.
What is Clarence Tablet 400 mg used for?
Clarence Tablet 400 mg is used for: Asthma, Chronic Obstructive Pulmonary Disease.
What are the side effects of Clarence Tablet 400 mg?
Patients taking xanthine-derivative medicines such as doxophylline may experience nausea, vomiting, stomach (epigastric) pain, headache, irritability, insomnia, a fast heartbeat, extra heartbeats (extrasystoles), and rapid breathing. Rarely, high blood sugar or protein in the urine can occur.
Can I take Clarence Tablet 400 mg during pregnancy or while breastfeeding?
In animal tests, the active ingredient of Doxophylline did not interfere with growth before or after birth. There isn't enough clinical evidence yet about how the medicine affects pregnant women, so its use during pregnancy should be weighed carefully case by case, looking at the risk against the benefit. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Clarence Tablet 400 mg?
An overdose of Doxophylline can cause severe cardiac arrhythmias and tonic-clonic seizures. These may be the first signs of intoxication. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Clarence Tablet 400 mg?
Keep in a dry place away from light and heat. Keep out of the reach of children.
Can I take other medicines with Clarence Tablet 400 mg?
Some medicines can interact with Doxophylline, for example: Erythromycin, Clindamycin, Cimetidine, Allopurinol, Caffeine, Lincomycin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Clarence Tablet 400 mg?
Clarence Tablet 400 mg is a prescription (Rx) medicine. Take it as your doctor advises.