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All price changes →Indications & Uses
Cabolin is used to stop breast milk production (lactation) soon after childbirth, stillbirth, abortion or miscarriage. It can also be used by mothers who choose not to continue breastfeeding. Beyond this, Cabolin is used to treat other conditions caused by hormonal disturbances that lead to abnormally high levels of prolactin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended starting dose of Cabergoline is 0.25 mg twice a week. Depending on the patient's serum prolactin level, the dose may be raised by 0.25 mg twice weekly, up to a maximum of 1 mg twice a week. Increases should be spaced at least 4 weeks apart so the physician can properly judge the response at each level. If higher doses bring no extra benefit, the lowest dose that gave the best response should be continued, and other treatment options considered. Once a normal serum prolactin level has been maintained for 6 months, Cabergoline can be stopped, with periodic prolactin checks afterward to see whether treatment needs to start again. To prevent milk production after delivery: a single 1 mg dose of Cabergoline, taken on the first day after delivery. To stop lactation after breastfeeding has already begun: 0.25 mg every 12 hours for two days. To lower prolactin levels in other conditions: treatment usually starts with one 0.5 mg tablet, split into two doses taken a few days apart over the week (for example, half a tablet on Monday and the other half on Thursday). The dose can then be raised gradually, up to a maximum of 4.5 mg, until a full response to treatment is achieved.
Side Effects
Cabolin (Cabergoline) is classified as pregnancy category B, but women who are pregnant or planning a pregnancy should still talk to their doctor before starting treatment. If pregnancy occurs and continues for a month or more, Cabolin should be stopped, since it suppresses milk production. For the same reason, anyone planning to breastfeed should not take this medicine.
Cautions & Contraindications
Warnings & Precautions
Do not use this medicine if you are hypersensitive (allergic) to Cabolin, to other medicines called ergot alkaloids (for example pergolide, bromocriptine, lisuride, ergotamine or ergometrine), or to any of the other ingredients in the tablet. It should also be avoided if you have severe liver disease; high blood pressure in pregnancy with associated swelling and protein in the urine (toxaemia of pregnancy); if you are taking anti-psychotic medicines or have a history of mental illness linked to childbirth (puerperal psychosis); if you are pregnant or breastfeeding; or if you have been treated with Cabolin for a long period and have or have had fibrotic reactions (scar tissue) affecting your heart. Dopamine agonists in general should not be used in patients with pregnancy-induced hypertension, such as pre-eclampsia or eclampsia, unless the potential benefit is judged to outweigh the possible risk. Starting doses higher than 1.0 mg may cause a drop in blood pressure on standing (orthostatic hypotension), so care should be taken when Cabolin is given alongside other medicines known to lower blood pressure. Cabolin is not indicated for stopping or suppressing normal breast-milk production. The use of bromocriptine, another dopamine agonist, for this purpose has been linked to cases of high blood pressure, stroke, and seizures. Because Cabolin is broken down mainly by the liver, it should be used with caution in patients with impaired liver function. In cases where pleural effusion, pulmonary fibrosis, or valve disease has been diagnosed, stopping Cabolin has been reported to lead to improvement of the associated signs and symptoms.
Contraindications
A history of serious mental illness, particularly psychotic disorders, rules out use of this medicine, as does liver or kidney disease. It should also be avoided in high blood pressure during pregnancy that occurs together with swelling and protein in the urine (toxaemia of pregnancy), and in anyone taking antipsychotic medicines or with a history of mental illness linked to childbirth (puerperal psychosis).