Phenylephrine Hydrochloride

Phenylephrine is an alpha-1 adrenergic receptor agonist. Following intravenous administration of phenylephrine, increases in systolic and diastolic blood pressures and arterial blood pressure are observed. The onset of blood pressure increase is rapid, typically within minutes. Following intravenous administration of phenylephrine hydrochloride, increases in systolic and diastolic blood pressures, mean arterial blood pressure, and total peripheral vascular resistance are observed. The onset of blood pressure increase following an intravenous bolus dose of phenylephrine hydrochloride is rapid, typically within minutes. As blood pressure increases following intravenous administration, vagal activity also increases, resulting in reflex bradycardia. Phenylephrine acts on most vascular beds, including the renal, pulmonary, and splanchnic arteries.