শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

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Mycophenolate Mofetil

Immunological Chemotherapy Prescription
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ইঙ্গিত

Graftcept in combination with corticosteroids and either ciclosporin or tacrolimus is indicated for- Prophylaxis of acute organ rejection and treatment of first or refractory organ rejection in patients receiving allogeneic renal transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic cardiac transplants. ... Read moreGraftcept in combination with corticosteroids and either ciclosporin or tacrolimus is indicated for- Prophylaxis of acute organ rejection and treatment of first or refractory organ rejection in patients receiving allogeneic renal transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic cardiac transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic hepatic transplants. Graftcept is indicated for induction and maintenance therapy of patients with Class III-V lupus nephritis (diagnosed according to International Society of Nephrology/Renal Pathology Society classification.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Mechanism of Action: Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA). MPA is a potent, selective, uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and it therefore inhibits the de novo pathway of guanosine nucleotide synthesis. The way MPA inhibits the enzymatic activity of IMPDH appears to be related to its ability to structurally mimic both the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. This prevents the oxidation of IMP to xanthose-5'-monophosphate, which is the committed step in de novo guanosine nucleotide biosynthesis. MPA has more potent cytostatic effects on lymphocytes than on other cells because T and B lymphocytes depend critically on de novo purine synthesis for their proliferation, whereas other cell types can rely on salvage pathways instead.

Pharmacodynamics: Mycophenolic acid, the active metabolite of mycophenolate mofetil, is a non-competitive, reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Inhibiting IMPDH blocks the de novo synthesis of guanosine nucleotides, which are necessary substrates for DNA and RNA synthesis. Unlike other cell types, which can use the salvage pathway, B and T lymphocytes depend on the de novo pathway to generate guanosine. Data from in vitro studies show that mycophenolic acid and/or mycophenolate mofetil inhibit mixed lymphocyte responses and human peripheral blood lymphocyte proliferation induced by a variety of mitogens and antigens. Mycophenolic acid reduces intracellular pools of guanosine triphosphate (GTP) and deoxyguanosine triphosphate (dGTP) in mitogen-stimulated human peripheral blood monocytes or T lymphocytic cell lines, but it has no effect on GTP concentrations in human neutrophils.

Pregnancy & Breastfeeding

Mycophenolate Mofetil should not be used during pregnancy or while breastfeeding. It has not been established as safe for use during labor and delivery either.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Transplant patients:Standard dosage for prophylaxis of renal rejection Adults: A dose of 1 g administered orally twice a day (daily dose of 2 g) is recommended for use in renal transplant patients. Children (aged 3 months to 18 years): Patients with a body surface area of 1.25 to 1.5 m2 may be prescribed Mycophenolate Mofetil Tablets at a dose of 750 mg twice daily (1.5 g daily dose). Patients with a body surface area >1.5 m2 may be prescribed Mycophenolate Mofetil tablets at a dose of 1 gm twice daily (2 g daily dose). Standard dosage for prophylaxis of cardiac rejection- Adults: A dose of 1.5 g administered orally (over not less than 2 hour) twice a day (daily dose of 3 g) is recommended for use in cardiac transplant patients. Children: no data are available for pediatric cardiac transplant patients. Standard dosage for prophylaxis of hepatic rejection- Adults: A dose of 1.5 g orally twice a day (daily dose of 3 g) is recommended for use in hepatic transplant patients Children: no data are available for pediatric hepatic transplant patients. Standard dosage for treatment of first or refractory renal rejection- Adults: A dose of 1.5 g administered orally twice a day (daily dose of 3 g) is recommended for management of first or refractory rejection. Children: no data are available for the treatment of first or refractory renal rejection in pediatric renal transplant patients. Lupus nephritis patients:Standard Dosage for Induction Therapy- Adults: A dose of 750 mg-1.5 g administered orally twice a day (daily dose of up to 3 g) is recommended Children: A dose of 600 mg/m2 administered orally twice a day (up to a maximum of 2 g daily) is recommended Standard Dosage for Maintenance Therapy- Adults: A dose of 500 mg-1 g administered orally twice a day is recommended Children: A dose of 300 mg/m2 administered orally twice a day is recommended Mycophenolate Mofetil should be used in combination with corticosteroids. Doses should be introduced gradually and adjusted according to clinical response. Therapeutic drug monitoring could help prevent sub-therapeutic exposure (Cmin≥3.0 mg/L or inter-dose AUC ≥35 h*mg/L).

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পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.