Pricing
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সব দামের পরিবর্তন →ইঙ্গিত ও ব্যবহার
Graftcept in combination with corticosteroids and either ciclosporin or tacrolimus is indicated for- Prophylaxis of acute organ rejection and treatment of first or refractory organ rejection in patients receiving allogeneic renal transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic cardiac transplants. ... Read moreGraftcept in combination with corticosteroids and either ciclosporin or tacrolimus is indicated for- Prophylaxis of acute organ rejection and treatment of first or refractory organ rejection in patients receiving allogeneic renal transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic cardiac transplants. Prophylaxis of acute organ rejection in patients receiving allogeneic hepatic transplants. Graftcept is indicated for induction and maintenance therapy of patients with Class III-V lupus nephritis (diagnosed according to International Society of Nephrology/Renal Pathology Society classification.
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Transplant patients:Standard dosage for prophylaxis of renal rejection Adults: A dose of 1 g administered orally twice a day (daily dose of 2 g) is recommended for use in renal transplant patients. Children (aged 3 months to 18 years): Patients with a body surface area of 1.25 to 1.5 m2 may be prescribed Mycophenolate Mofetil Tablets at a dose of 750 mg twice daily (1.5 g daily dose). Patients with a body surface area >1.5 m2 may be prescribed Mycophenolate Mofetil tablets at a dose of 1 gm twice daily (2 g daily dose). Standard dosage for prophylaxis of cardiac rejection- Adults: A dose of 1.5 g administered orally (over not less than 2 hour) twice a day (daily dose of 3 g) is recommended for use in cardiac transplant patients. Children: no data are available for pediatric cardiac transplant patients. Standard dosage for prophylaxis of hepatic rejection- Adults: A dose of 1.5 g orally twice a day (daily dose of 3 g) is recommended for use in hepatic transplant patients Children: no data are available for pediatric hepatic transplant patients. Standard dosage for treatment of first or refractory renal rejection- Adults: A dose of 1.5 g administered orally twice a day (daily dose of 3 g) is recommended for management of first or refractory rejection. Children: no data are available for the treatment of first or refractory renal rejection in pediatric renal transplant patients. Lupus nephritis patients:Standard Dosage for Induction Therapy- Adults: A dose of 750 mg-1.5 g administered orally twice a day (daily dose of up to 3 g) is recommended Children: A dose of 600 mg/m2 administered orally twice a day (up to a maximum of 2 g daily) is recommended Standard Dosage for Maintenance Therapy- Adults: A dose of 500 mg-1 g administered orally twice a day is recommended Children: A dose of 300 mg/m2 administered orally twice a day is recommended Mycophenolate Mofetil should be used in combination with corticosteroids. Doses should be introduced gradually and adjusted according to clinical response. Therapeutic drug monitoring could help prevent sub-therapeutic exposure (Cmin≥3.0 mg/L or inter-dose AUC ≥35 h*mg/L).
পার্শ্বপ্রতিক্রিয়া
The main side effects reported with Graftcept are diarrhoea, low white blood cell count (leukopenia), sepsis, fungal infection of the digestive tract (gastrointestinal candidiasis), urinary tract infection, herpes simplex and vomiting. There is also evidence that certain types of infection, such as opportunistic infections, occur more often.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Mycophenolic acid tablets should be used with caution, because they can increase the risk of new or reactivated viral infections. These include reactivation of latent viruses such as hepatitis B or hepatitis C, and infections caused by polyomaviruses. They can cause blood dyscrasias, including pure red cell aplasia (PRCA). They can cause serious GI tract complications, such as gastrointestinal bleeding, perforations and ulcers. They may increase the risk of developing lymphomas and other malignancies, particularly of the skin. Live vaccines should be avoided during treatment with Mycophenolic acid, and patients should not donate blood during therapy.
নিষেধাজ্ঞা
Mycophenolate mofetil should not be used by anyone who is allergic (hypersensitive) to mycophenolic acid or to any of the other ingredients in the product. It must not be taken during pregnancy, because it can damage genetic material and cause birth defects. It should also not be used by women who are breastfeeding.