শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

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Community data Updated 2 মাস আগে
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ইঙ্গিত

Psoriasis

Aprima is used to treat adults with active psoriatic arthritis, and adults with moderate to severe plaque psoriasis who are suitable candidates for phototherapy or systemic therapy.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Apremilast is a novel, orally available small molecule that inhibits type 4 cyclic nucleotide phosphodiesterase (PDE-4). PDE-4 is a cyclic adenosine monophosphate (cAMP) specific phosphodiesterase found mainly in inflammatory cells. By inhibiting PDE-4, apremilast raises intracellular levels of cAMP, which in turn suppresses the production of several proinflammatory mediators, including PDE-4, TNF-alpha, interleukin-2 (IL-2), interferon-gamma, leukotrienes, and nitric oxide synthase. Because it acts on a central component of the inflammatory signaling cascade rather than a single inflammatory marker, PDE-4 inhibition may help restore the natural balance between pro-inflammatory and anti-inflammatory signaling.

Pregnancy & Breastfeeding

Pregnancy Category C. It is not known whether Apremilast or its breakdown products pass into human breast milk, though it has been found in the milk of nursing mice. As a precaution, it should be used carefully in breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Apremilast is started with a five-day dose titration, then continued at the usual maintenance dose of 30 mg taken by mouth twice daily from Day 6 onward. The gradual increase is meant to reduce the stomach and bowel upset that can occur when treatment begins. Apremilast may be taken with or without food. On Day 1, take 10 mg in the morning. On Day 2, take 10 mg in the morning and 10 mg in the evening. On Day 3, take 10 mg in the morning and 20 mg in the evening. On Day 4, take 20 mg in the morning and 20 mg in the evening. On Day 5, take 20 mg in the morning and 30 mg in the evening. From Day 6, take 30 mg twice daily. In patients with severe kidney impairment, the dose should be lowered to 30 mg once daily. For the initial titration in these patients, only the morning doses of the schedule should be taken and the evening doses skipped.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.

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