Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Apremilast). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Otelast 10 এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Apremilast is started with a five-day dose titration, then continued at the usual maintenance dose of 30 mg taken by mouth twice daily from Day 6 onward. The gradual increase is meant to reduce the stomach and bowel upset that can occur when treatment begins. Apremilast may be taken with or without food. On Day 1, take 10 mg in the morning. On Day 2, take 10 mg in the morning and 10 mg in the evening. On Day 3, take 10 mg in the morning and 20 mg in the evening. On Day 4, take 20 mg in the morning and 20 mg in the evening. On Day 5, take 20 mg in the morning and 30 mg in the evening. From Day 6, take 30 mg twice daily. In patients with severe kidney impairment, the dose should be lowered to 30 mg once daily. For the initial titration in these patients, only the morning doses of the schedule should be taken and the evening doses skipped.
পার্শ্বপ্রতিক্রিয়া
The most common side effects of Aprima are nausea, diarrhoea and headache. Less common side effects include upper respiratory tract infection, vomiting, nasopharyngitis, abdominal pain, hypersensitivity, gastro-oesophageal reflux disease, dyspepsia, fatigue, decreased appetite, cough, rash and insomnia.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Treatment with Aprima is associated with an increase in adverse reactions of depression. Patients, their caregivers and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes, and to contact their healthcare provider if such changes occur. Prescribers should carefully weigh the risks and benefits of continuing treatment with Aprima if such events occur. During the controlled period of the studies in psoriatic arthritis, a weight decrease of between 5% and 10% of body weight was reported in 10% of subjects treated with Aprima 30 mg twice daily, compared with 3.3% of those treated with placebo.
নিষেধাজ্ঞা
Apremilast should not be given to anyone who has a known allergy (hypersensitivity) to Apremilast itself or to any other ingredient in the tablet.