ইঙ্গিত ও ব্যবহার
Arbecin is used to prevent uterine atony (failure of the womb to contract) and postpartum haemorrhage (excessive bleeding) after the baby has been delivered by planned caesarean section performed under epidural or spinal anaesthesia.
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
A single 100 mcg dose of carbetocin is given intravenously as a slow bolus injection over 1 minute. It is given only after the baby has been delivered by caesarean section under epidural or spinal anaesthesia. Carbetocin is for single-dose use only.
পার্শ্বপ্রতিক্রিয়া
Between 10% and 40% of patients experienced nausea, vomiting, abdominal pain, itchy skin, raised body temperature, trembling and weakness. Less common side effects, affecting 1% to 5% of patients, included back pain, dizziness, a metallic taste, anaemia, sweating, chest pain, shortness of breath (dyspnoea), chills, a rapid heartbeat (tachycardia) and anxiety.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
If a patient does not achieve an adequate uterine contraction after a single injection of Arbecin, more aggressive treatment with additional doses of oxytocin or ergometrine is warranted. Because Arbecin is closely related in structure to oxytocin, hyponatraemia may occur. Arbecin should be used with caution in patients with epilepsy, migraine, asthma or any condition in which a rapid increase in extracellular water could pose a hazard to an already overburdened system. Patients with eclampsia or pre-eclampsia should be monitored for changes in blood pressure. Arbecin is not recommended for use in elderly patients.
নিষেধাজ্ঞা
Carbetocin acts for much longer than oxytocin, so once it has been given, the uterine contractions it produces cannot be stopped simply by withdrawing the drug. For this reason, carbetocin must never be given before the baby has been delivered, for any reason, including elective or medical induction of labour. If carbetocin were used inappropriately during pregnancy, it could in theory produce the same effects as an oxytocin overdose: overstimulation of the uterus with strong (hypertonic) or prolonged (tetanic) contractions, tumultuous labour, uterine rupture, tears of the cervix and vagina, postpartum haemorrhage, reduced blood flow through the placenta with variable slowing of the fetal heart rate, fetal hypoxia, hypercapnia, or death. Carbetocin should not be used in anyone with a history of hypersensitivity to oxytocin or carbetocin. It should also not be used in patients with cardiovascular disease, particularly coronary artery disease, valvular heart disease, cardiomyopathy, or heart failure. Carbetocin is not intended for use in children.