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Other brands with the same active ingredient
These brands contain the same active ingredient (Chlorpromazine Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Cepron এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Adults, in general medicine and psychiatry, oral route: the average daily dose is 30 to 75 mg in mild cases, or 75 to 100 mg in more severe cases, given in divided doses. It is occasionally necessary to give a higher dosage, which, when increased gradually, can reach 900 mg or more per day in some psychiatric patients. Once the optimum dosage has been reached, it is maintained for as long as necessary to control symptoms during the critical phase of the illness. Eventually, however, it should be reduced gradually so the patient can be maintained on the lowest effective dosage. Adults, in surgery and anesthesia, to potentiate hypnotics, analgesics and anesthetics, and as an antiemetic, oral route: doses of 25 to 50 mg are given 2 to 3 hours before anesthesia and every 4 to 6 hours after surgery. Children: the usual single dose is 1/4 mg per pound (1/2 mg/kg) by oral route. This dose can be repeated every 4 to 6 hours as needed. The normal daily dose is 40 mg for a child of 5 years (40 pounds), and 75 mg for children aged 5 to 12 years (50 to 100 pounds), except in psychiatric patients, where dosages can be progressively increased above these levels. For surgery and anesthesia, the dose is 1/4 mg per pound, given by the same method recommended for adults.
পার্শ্বপ্রতিক্রিয়া
Drowsiness often occurs when treatment begins but usually eases or fades once the dose is lowered. Orthostatic hypotension is also seen occasionally in the early stage of treatment, especially with high doses. Dystonic and extrapyramidal reactions can appear during prolonged treatment with elevated dosages, but these can be resolved by reducing the dose or giving an antiparkinsonian agent. Other side effects that occur less often include nasal congestion, blurred vision, dry mouth, sedation, nausea, constipation, changes in libido, gynecomastia, weight gain, pigmentation of the skin and cornea, photosensitivity, blood dyscrasias, leukopenia, eosinophilia and EEG changes. Very rare cases of QT interval prolongation have been reported. There have been isolated reports of sudden death, possibly of cardiac origin, as well as cases of unexplained sudden death in patients receiving neuroleptic phenothiazines. Cholestatic jaundice and liver injury, mainly of cholestatic or mixed type, are rarely reported in patients treated with Opsonil. Systemic lupus erythematosus has been reported very rarely in patients treated with Opsonil. In some cases, positive anti nuclear antibodies may be seen without evidence of clinical disease. Priapism has been reported very rarely in patients treated with Opsonil.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Opsonil can intensify the effects of other phenothiazines and CNS depressants. When treatment begins, the usual doses of barbiturates, analgesics, narcotics, or antihistamines should be reduced by half. Patients should be warned against drinking alcohol while on Opsonil therapy. Neuroleptic phenothiazines may worsen QT interval prolongation, and this effect is more pronounced in the presence of bradycardia, hypokalemia, and congenital or acquired (e.g., drug-induced) QT prolongation. Opsonil should be used with caution in patients with arteriosclerosis, cardiovascular disease, or other conditions in which a sudden drop in blood pressure must be avoided. If hypotension does occur and a hypertensive agent is needed, norepinephrine should be used rather than epinephrine, since the latter can worsen hypotension. Because of its anticholinergic properties, Opsonil must also be used with caution in patients with glaucoma or prostatic hypertrophy. During prolonged therapy, particularly at high doses, blood counts and liver function tests should be performed at regular intervals. Drowsiness may occur early in treatment, so patients should be warned against driving or engaging in activities that require mental alertness until this effect has passed. Phenothiazines can trigger epileptic seizures by lowering the seizure threshold, so during Opsonil therapy, the patient's usual anticonvulsant medication should be continued at the same dose. Because of its antiemetic effect, Opsonil can mask symptoms of intracranial hypertension or intestinal obstruction. False positive or negative pregnancy test results have occurred in patients receiving phenothiazine therapy.
নিষেধাজ্ঞা
Contraindicated in patients with severe central nervous system depression or coma resulting from alcohol, barbiturates, analgesics, or other CNS depressants. It should also be avoided in patients with blood dyscrasias, severe liver disease, or known sensitivity to phenothiazines.