Pethidine Cyclizine Hydrochloride
ModerateCyclizine Hydrochloride can make pethidine more sedating than usual, so you may feel far drowsier or more sleepy than you would expect from either medicine on its own. Cyclizine can also work against the helpful effects that opioid painkillers such as pethidine have on the heart and blood circulation, so those benefits may be reduced when the two are taken together.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.