Celeste Tadalafil Isosorbide Dinitrate + Hydralazine Hydrochloride
ModeratePDE5 inhibitors such as avanafil, sildenafil, vardenafil and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.