Canvo Voriconazole Venetoclax
MajorVoriconazole should not be taken together with Venetoclax when you are starting Venetoclax or while the dose is being stepped up slowly. Voriconazole strongly slows down the enzyme (CYP3A) that helps clear Venetoclax from the body. This can raise Venetoclax levels in the blood and increase the risk of tumour lysis syndrome (TLS). TLS is a serious problem in which cancer cells break down too quickly and release their contents into the blood. Because of this risk, the leaflet lists the combination as contraindicated in this phase.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.