Xifos Ifosfamide Itraconazole
ModerateItraconazole is a CYP3A4 inhibitor, meaning it slows down the CYP3A4 enzyme in the body. Ifosfamide (Ifodex) needs this enzyme to change into its active, alkylating form. If you take the two together, less of the active form may be made, and Ifodex may work less well. Other CYP3A4 inhibitors can do the same. These include ketoconazole, fluconazole, sorafenib, aprepitant, fosaprepitant, grapefruit and grapefruit juice.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.