Xifos Ifosfamide Fluconazole
ModerateFluconazole is a CYP3A4 inhibitor, which means it slows down the CYP3A4 enzyme in your body. Ifosfamide (Ifodex) needs this enzyme to change into the active forms that fight cancer cells. When fluconazole slows the enzyme, less of the medicine may be converted into its active forms. Ifodex may then work less well against the cancer.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.