Voricare 50 Voriconazole Ponatinib Hydrochloride
ModerateVoriconazole is a strong CYP3A inhibitor. It slows down the liver enzyme that breaks down ponatinib, so more ponatinib can stay in your body than usual. Take the two together with care. Your doctor may think about lowering the starting dose of ponatinib to 30 mg. Grapefruit juice acts the same way, so avoid it while you are on ponatinib.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.