Pazorest Pazopanib Hydrochloride Simvastatin
ModerateTaking Pazoren (Pazopanib) together with Simvastatin makes a rise in the liver test ALT more likely. In trials of Pazoren alone, ALT went above 3 times the upper limit of normal (3 x ULN) in 126 of 895 patients (14%) who were not on statins. Among 11 of 41 patients (27%) who were also taking Simvastatin, it went above that same level. If ALT rises in a patient who is also on Simvastatin, follow the dosing guidelines for Pazoren, or consider using something other than Pazoren.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.