Rivacard 15 Rivaroxaban Verapamil Hydrochloride
MajorVerapamil is one of the medicines that block both P-gp and CYP3A4 together. Taking it with Rivaroxaban raises the amount of Rivaroxaban in your body and strengthens its effects. Factor Xa is blocked more, and PT (prothrombin time) becomes longer. For this reason the two medicines should not be taken together. Ketoconazole, ritonavir, clarithromycin, erythromycin, fluconazole, diltiazem and dronedarone act in the same way.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.