Drug Interaction Checker

Find out if your medicines are safe to take together.

1 Add each medicine you take: the brand on the box or the medicine inside it.
2 We check every pair, including each ingredient of combination medicines.
3 See what could happen and what to do, in plain language.

Your medicines

Take these together with care

We found interactions that usually need care rather than stopping a medicine. Your doctor may adjust a dose or check on you more often.

1 Moderate 1 pair checked

1 interaction

Docegen 80 Docetaxel Sorafenib Tosylate

Moderate

Sorafenib (Sofen) can raise the amount in the body of medicines that are cleared by the UGT1A1 and UGT1A9 enzymes, so their exposure may go up when taken together with it. This was seen with Docetaxel. In the study, Docetaxel (75 or 100 mg/m2, given every 21 days) was combined with Sofen (200 or 400 mg twice daily). Sofen was paused for 3 days around each Docetaxel dose. Even so, Docetaxel AUC (the total amount of medicine in the blood over time) rose by 36-80%. Its Cmax (the peak level in the blood) rose by 16-32%.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?

Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.