Voxamin XR-150 Fluvoxamine Maleate Tizanidine Hydrochloride
MajorDo not take Tizanidine (Tizalud) together with Fluvoxamine. Fluvoxamine blocks CYP1A2, the enzyme your body uses to break down tizanidine, and the leaflet lists this combination as contraindicated. Ciprofloxacin, which acts the same way, is also on that list. When tizanidine was taken with fluvoxamine, the AUC (the total amount of the medicine in the blood over time) of tizanidine rose 33-fold. With ciprofloxacin, it rose 10-fold.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.