Tizalex Tizanidine Hydrochloride Cimetidine
MajorCimetidine blocks CYP1A2, an enzyme in the liver that helps the body break down tizanidine. For this reason, the leaflet says Tizanidine and Cimetidine should not be taken together.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.