Tramadol 100 SR Tramadol Hydrochloride Bupropion Hydrochloride
ModerateBupropion (Zybex SR) and tramadol both make a seizure (convulsion) more likely, and taking them together adds to that risk. So they should be used together only with extreme caution. Take them together only if your doctor has said so and is watching you closely.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.