ROXOLYTE F.C TABLET Rivaroxaban Fluconazole
MajorTaking fluconazole together with rivaroxaban increases the level of rivaroxaban in the body and its effects, such as factor Xa inhibition and PT prolongation. Fluconazole is a combined P-gp and CYP3A4 inhibitor, so taking these two medicines together should be avoided.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.