Drug Interaction Checker

Find out if your medicines are safe to take together.

1 Add each medicine you take: the brand on the box or the medicine inside it.
2 We check every pair, including each ingredient of combination medicines.
3 See what could happen and what to do, in plain language.

Your medicines

Serious interaction found

At least one pair of your medicines should not be taken together without a doctor's advice. Read the details below and talk to your doctor or pharmacist before your next dose.

1 Major 1 Moderate 1 pair checked

2 interactions

Rilona 50/200 Lopinavir + Ritonavir Methylergonovine Maleate

Major

Lopinavir + Ritonavir must not be taken together with methylergonovine. It is also on the do-not-combine list with several other medicines. These are: Alpha 1 adrenoreceptor antagonist (alfuzosin), the antimycobacterial rifampin, and ergot derivatives (dihydroergotamine, ergotamine and methylergonovine). The list also includes the gut motility agent cisapride, the HMG-CoA reductase inhibitors lovastatin and simvastatin, and the PDE5 enzyme inhibitor sildenafil when it is used for pulmonary arterial hypertension. The last two are the neuroleptic pimozide and the sedative/hypnotics triazolam and orally taken midazolam.

What should I do?

These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.

Rilona 50/200 contains Ritonavir Methylergonovine Maleate

Moderate

Ritonavir is one of the strong CYP3A4 inhibitors. That means it slows down the liver enzyme that clears methylergonovine from the body. Taking the two together can raise the level of methylergonovine in the blood, and that is exactly the situation the leaflet is warning about. Ritonavir belongs to the same group as the other HIV protease inhibitors named here (indinavir, nelfinavir, delavirdine), alongside macrolide antibiotics such as erythromycin and clarithromycin, and azole antifungals such as ketoconazole and itraconazole.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?

Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.