Soracent 200 Sorafenib Ifosfamide
ModerateSorafenib is a CYP3A4 inhibitor. CYP3A4 is a liver enzyme that helps the body turn Ifosfamide into its active form, the form that attacks cancer cells. Other CYP3A4 inhibitors include ketoconazole, fluconazole, itraconazole, aprepitant, fosaprepitant, grapefruit and grapefruit juice. When Ifosfamide is taken with Sorafenib, less of it may be converted into these active alkylating metabolites. This may make Ifosfamide treatment work less well.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.