Apilast 10 Apremilast Phenobarbital
MajorTaking Apremilast (Aprima) together with Phenobarbital is not recommended. The same warning applies to Rifampin, Carbamazepine and Phenytoin. If you are already taking both, talk to your doctor or pharmacist before you change or stop either one.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.