Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Drug Interaction Checker

Find out if your medicines are safe to take together.

  1. 1 Add each medicine you take: the brand on the box or the medicine inside it.
  2. 2 We check every pair, including each ingredient of combination medicines.
  3. 3 See what could happen and what to do, in plain language.

Take these together with care

We found interactions that usually need care rather than stopping a medicine. Your doctor may adjust a dose or check on you more often.

2 Moderate 1 pair checked

2 interactions

Acmegra 100 Sildenafil Bosentan Monohydrate

Moderate

Bosentan may lower the blood level of sildenafil, so sildenafil may work less well.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Acmegra 100 contains Sildenafil Citrate Bosentan Monohydrate

Moderate

In a study of healthy male volunteers, taking sildenafil at steady state (80 mg t.i.d.) together with bosentan at steady state (125 mg b.i.d.) resulted in a 63% decrease in sildenafil AUC and a 55% decrease in sildenafil Cmax. Bosentan is an endothelin receptor antagonist and a moderate inducer of CYP3A4, CYP2C9 and possibly of cytochrome P450 2C19.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?
Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.