Xevirol Everolimus Palbociclib
ModeratePalbociclib (Palbokin) can raise the amount of Everolimus in your body. Everolimus is a sensitive CYP3A substrate, meaning the CYP3A enzyme breaks it down. It also has a narrow therapeutic index, so a small rise in its level can matter. Your doctor may need to lower your Everolimus dose. Other medicines in this group include alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus and tacrolimus.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.