Prasugrel (Appras) can be taken together with digoxin. The leaflet lists digoxin among the medicines that are fine to use with it, along with aspirin (75 mg to 325 mg a day), heparin, GPIIb/IIIa inhibitors, statins, and acid-reducing medicines such as proton pump inhibitors and H2 blockers.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.