Simastin Simvastatin Ticagrelor
MajorTaking Ticagrelor with simvastatin doses greater than 40 mg is not recommended, because simvastatin is metabolised by CYP3A4.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.