Opifen Fentanyl Citrate Itraconazole
ModerateTaking fentanyl (Durogesic) together with itraconazole may make its effects stronger or make them last longer. The leaflet lists itraconazole among a group of medicines that can do this. The group includes different antifungals, macrolide antibiotics and CNS depressant drugs, such as ketoconazole, troleandomycin, clarithromycin, nelfinavir and nefazadone.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.