Drug Interaction Checker

Find out if your medicines are safe to take together.

1 Add each medicine you take: the brand on the box or the medicine inside it.
2 We check every pair, including each ingredient of combination medicines.
3 See what could happen and what to do, in plain language.

Your medicines

Serious interaction found

At least one pair of your medicines should not be taken together without a doctor's advice. Read the details below and talk to your doctor or pharmacist before your next dose.

1 Major 1 pair checked

1 interaction

Fentanyl Fentanyl Lorlatinib

Major

Lorlatinib can lower the amount of certain medicines in your blood by speeding up how fast the body clears them. These are medicines processed by the CYP3A4/5 enzymes and have a narrow safety margin, meaning even a small change in their level can matter. Fentanyl is one of them. Others include alfentanil, ciclosporin, dihydroergotamine, ergotamine, hormonal contraceptives, pimozide, quinidine, sirolimus and tacrolimus. Taking lorlatinib (Lorbrexen) with fentanyl may leave you with less fentanyl than intended, so the pain relief may be weaker. It is best to avoid taking them together.

What should I do?

These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?

Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.