Zoleta Letrozole Cimetidine
ModerateClinical studies show that taking letrozole and cimetidine together does not cause clinically significant drug reactions. This is true even though cimetidine is a known inhibitor of one of the cytochrome P450 isoenzymes capable of metabolising letrozole in vitro.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.