Kumucin Erythromycin Venetoclax
MajorVenetoclax and Erythromycin should not be taken together at the start of treatment or while the dose is being raised step by step. Erythromycin is a moderate CYP3A inhibitor, which means it slows the liver enzyme that clears Venetoclax from the body. Venetoclax then builds up and the level in the blood rises. That raises the risk of TLS (tumour lysis syndrome), a dangerous problem where cancer cells break down too fast and release their contents into the blood. It is not on the leaflet's list of combinations that are banned outright, but it should still be avoided in this phase. Do not start or stop Erythromycin on your own. If you have been prescribed both, ask your doctor or pharmacist what to do.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.