U Methacin Indomethacin Chlorthalidone
ModerateIndomethacin can weaken the diuretic and blood pressure-lowering effects of chlorthalidone. There have also been isolated reports of kidney function getting worse in predisposed patients.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.