Remac Clarithromycin Venetoclax
MajorVenetoclax and clarithromycin must not be taken together when you are starting venetoclax or while the dose is being slowly stepped up. Clarithromycin is a strong CYP3A inhibitor, and using it in this phase raises the risk of tumour lysis syndrome (TLS). This is a rule against the combination, not just a caution. If you have been prescribed venetoclax and need an antibiotic, tell your doctor before you take clarithromycin.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.