Hydrocortisone Acetate + Neomycin Sulphate may not work as well as expected if you are also taking Phenytoin. In other words, Phenytoin can weaken the effect of this medicine, so you may not get the full benefit from it.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.