Rifcin Rifampicin Crizotinib
MajorRifampicin is a strong CYP3A inducer. That means it speeds up the liver enzyme that breaks down crizotinib, so the amount of crizotinib in your blood can fall. With less of it in your body, crizotinib may not work as well against the cancer. The leaflet says these two medicines should not be taken together. If you are on crizotinib and a doctor prescribes rifampicin (for example for TB), tell them so they can choose another option.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.