Neocin Neomycin Sulphate Neostigmine Methylsulphate
ModerateNeomycin can add to the muscle-weakening effect of neostigmine methylsulphate. Neomycin has a mild but definite action that blocks the signal from nerve to muscle, and this can make muscle weakness worse. This matters most in people with myasthenia gravis, because neostigmine methylsulphate is used to keep their muscles working. Neomycin, like streptomycin and kanamycin, should be given to such patients only when it is clearly needed. If it is used, the doctor must adjust the dose of neostigmine methylsulphate carefully.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.