Pyrison Pyrimethamine Deucravacitinib
MinorIn clinical trials, Deucravacitinib worked in the body the same way when it was taken together with any of these medicines. No clinically significant difference was seen with cyclosporine (a dual Pgp/BCRP inhibitor), fluvoxamine (a CYP1A2 inhibitor), ritonavir (a CYP1A2 inducer), diflunisal (a UGT 1A9 inhibitor), famotidine (an H2 receptor antagonist) or rabeprazole (a proton pump inhibitor). Pyrimethamine, an OCT1 inhibitor, was also on this list, so taking it with Deucravacitinib did not cause a clinically significant change.
Little or no effect is expected. You usually do not need to change anything, but still tell your doctor or pharmacist about every medicine you take.