Drug Interaction Checker

Find out if your medicines are safe to take together.

1 Add each medicine you take: the brand on the box or the medicine inside it.
2 We check every pair, including each ingredient of combination medicines.
3 See what could happen and what to do, in plain language.

Your medicines

Take these together with care

We found interactions that usually need care rather than stopping a medicine. Your doctor may adjust a dose or check on you more often.

1 Moderate 1 pair checked

1 interaction

G Amitriptyline Amitriptyline Hydrochloride Rifampicin + Isoniazid

Moderate

Rifampicin, one of the two medicines in this combination, can lower the blood levels of many other medicines, so they may not work as well as they should. These include phenytoin and other anti-seizure medicines, disopyramide, blood thinners taken by mouth, and antifungals such as ketoconazole. They also include barbiturates, beta-blockers, diltiazem, chloramphenicol, clarithromycin, steroids, ciclosporin, digoxin-type heart medicines, dapsone, diazepam, doxycycline, ciprofloxacin-type antibiotics, haloperidol, sulfonylurea diabetes tablets, levothyroxine, methadone and strong painkillers. If you take amitriptyline with this medicine, check with your doctor or pharmacist first.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?

Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.