Promactil Chlorpromazine Hydrochloride Fluvoxamine Maleate
ModerateFluvoxamine can raise the level of chlorpromazine in your blood. It does this by slowing down CYP1A2, an enzyme in the liver that normally helps break chlorpromazine down. When less of the drug is cleared, more of it stays in your body, so its effects and side effects, such as drowsiness, can become stronger. If you need both medicines, take them only under a doctor's supervision, because your dose may need to be adjusted.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.