Indomethacin Indomethacin Spironolactone
ModerateIndomethacin can slow down how quickly your body gets rid of canrenone, which is the active substance Spironolactone turns into inside the body. Mefenamic acid, another pain-relief medicine, has the same effect. So if you take Spironolactone with either of them, ask your doctor or pharmacist first.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.