Zaleplon has been shown to have little effect on how the body handles digoxin. Taking the two together did not noticeably change how digoxin is absorbed, spread or cleared. Digoxin's level in the blood is therefore not expected to shift because of zaleplon.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.