Brodactam Piperacillin + Tazobactam Methotrexate
ModerateLimited data suggests that taking piperacillin and tazobactam together with methotrexate may reduce how quickly your body clears methotrexate. This is because both medicines compete to be removed through the kidneys.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.