Indications
Nitrest Capsules work on the brain's GABA-A receptors and are used for the short-term relief of transient insomnia in adults under 65 who have trouble falling asleep.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Zolpidem is a positive modulator at the GABA A receptor and is thought to produce its effects in the short-term treatment of transient insomnia by binding to the benzodiazepine site on GABA A receptors that contain the α1 subunit, which increases how often the chloride channel opens and thereby inhibits neuronal excitation. Zolpidem binds to GABA A receptors with greater affinity for the α1 subunit than for receptors containing the α2 or α3 subunit, and it shows no appreciable binding affinity for GABA A receptors containing the α5 subunit. This binding profile may account for the relative absence of muscle-relaxant effects seen in animal studies. Zolpidem also shows no appreciable binding affinity for dopaminergic D2, serotonergic 5HT2, adrenergic, histaminergic, or muscarinic receptors.
Pregnancy & Breastfeeding
A pregnancy exposure registry tracks outcomes in women who take psychiatric medications, including zolpidem tartrate, during pregnancy. Limited published data show that zolpidem tartrate can pass into human breast milk, and some infants who were breastfed while their mothers used it have shown excess sedation as a result.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.