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Zolmitriptan

5-HT Agonists Prescription
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Indications

Zolmit is used to treat migraine attacks in adults as they occur, whether or not the migraine is accompanied by aura.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Migraines are thought to result from local widening of blood vessels in the skull and the release of certain sensory nerve chemicals through nerve endings in the trigeminal system. Zolmitriptan is believed to relieve migraine headaches by acting on 5-HT1B/1D receptors found on the blood vessels inside the skull and on sensory nerves of the trigeminal system. This action narrows the cranial blood vessels and reduces the release of neuropeptides that promote inflammation.

Pregnancy & Breastfeeding

Pregnancy Category C. Zolmitriptan should only be used in pregnancy if the potential benefit to the mother outweighs the potential risk to the unborn baby. It is not known whether Zolmitriptan passes into breast milk. Because of this, a decision should be made between stopping breastfeeding or stopping the medicine, weighing how important the drug is for the mother's treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tablet: The recommended starting dose is 2.5 mg. The maximum single dose is 5 mg. If the migraine has not eased within 2 hours of taking Zolmitriptan, or comes back after briefly improving, a second dose may be given at least 2 hours after the first. The maximum dose in any 24 hour period is 10 mg. Nasal Spray: Give one 5 mg dose of Zolmitriptan Nasal Spray for an acute migraine attack. If the headache returns, the dose may be repeated after 2 hours, and the total should not exceed 10 mg in any 24 hour period. In controlled clinical trials, single 5 mg doses of zolmitriptan nasal spray given into one nostril were effective for treating acute migraines in adults. Response to Zolmitriptan Nasal Spray can vary from person to person. A 5 mg nasal spray dose behaves in the body much like a 5 mg oral dose. Doses lower than 5 mg can only be given as an oral formulation, so the dose and route of administration should be chosen for each patient individually. Placebo-controlled trials have not established how effective a second dose is, and the safety of treating more than an average of four headaches within a 30 day period has not been established.