Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago

Triamcinolone Acetonide

Corticosteroid Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Allergic Rhinitis

Intramuscular use: When treatment by mouth is not practical, injectable corticosteroid therapy, including Cenolon injection, is indicated for intramuscular use in the following situations. Rheumatic disorders: as short-term add-on therapy to carry the patient through an acute episode or flare-up in acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis, including juvenile rheumatoid arthritis. Allergic states: to control severe or disabling allergic conditions that have not responded to adequate trials of conventional treatment, in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, and transfusion reactions. Dermatologic diseases: bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, and severe erythema multiforme (Stevens-Johnson syndrome). Endocrine disorders: primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used together with mineralocorticoids where applicable, and in infancy mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, and nonsuppurative thyroiditis. Gastrointestinal diseases: to carry the patient through a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic disorders: acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, and selected cases of secondary thrombocytopenia. Neoplastic diseases: for the palliative management of leukemias and lymphomas. Nervous system: acute exacerbations of multiple sclerosis, and cerebral edema associated with a primary or metastatic brain tumor or with craniotomy. Ophthalmic diseases: sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammatory conditions that do not respond to topical corticosteroids. Renal diseases: to induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or nephrotic syndrome due to lupus erythematosus. Respiratory diseases: berylliosis, fulminating or disseminated pulmonary tuberculosis when used together with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, and symptomatic sarcoidosis. Miscellaneous: trichinosis with neurologic or myocardial involvement, and tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Intra-articular use: Intra-articular or soft tissue administration of Cenolon injection is indicated as short-term add-on therapy to carry the patient through an acute episode or flare-up in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis, or osteoarthritis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Triamcinolone Acetonide occurs as a white to cream-colored, crystalline powder having not more than a slight odor and is practically insoluble in water and very soluble in alcohol. It is a synthetic glucocorticoid corticosteroid with anti-inflammatory action. This formulation is suitable for intramuscular and intra-articular use only.Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. Naturally occurring glucocorticoids (e.g. hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Synthetic analogs such as triamcinolone are primarily used for their anti-inflammatory effects in disorders of many organ systems. Triamcinolone injection has an extended duration of effect which may be sustained over a period of several weeks. Studies indicate that following a single intramuscular dose of 60 mg to 100 mg of Triamcinolone Acetonide, adrenal suppression occurs within 24 to 48 hours and then gradually returns to normal, usually in 30 to 40 days. This finding correlates closely with the extended duration of therapeutic action achieved with the drug.

Pregnancy & Breastfeeding

Pregnancy Category C. In animal studies, corticosteroids have been shown to cause birth defects when given at doses equivalent to those used in humans. For this reason, corticosteroids should be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the unborn baby. Corticosteroids taken systemically can pass into breast milk and may slow a nursing infant's growth, affect the body's natural corticosteroid production, or cause other unwanted effects. Corticosteroids should therefore be used with caution in breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: General Dosage: The initial dose of Triamcinolone injection may vary from 2.5 mg to 100 mg per day, depending on the specific disease being treated. However, in certain overwhelming, acute, life-threatening situations, doses exceeding the usual range may be justified. Dosage requirements vary and must be individualised according to the disease under treatment and the patient's response. Administration: Strict aseptic technique is mandatory. The vial should be shaken before use to ensure a uniform suspension. Before withdrawal, the suspension should be inspected for clumping or a granular appearance (agglomeration). Systemic Dosage: The suggested initial dose is 60 mg, injected deeply into the gluteal muscle. Atrophy of subcutaneous fat may occur if the injection is not given properly. The dose is usually adjusted within the range of 40 mg to 80 mg, depending on the patient's response and the duration of relief. However, some patients may be well controlled on doses as low as 20 mg or less. Pediatric patients: The range of initial doses is 0.11 to 1.6 mg/kg/day, given in 3 or 4 divided doses. Administration: For systemic therapy, the injection should be made deeply into the gluteal muscle. For adults, a minimum needle length of 11/2 inches is recommended. In obese patients, a longer needle may be required. Use alternative sites for subsequent injections. Local Dosage: Intra-articular administration: A single local injection of Triamcinolone Acetonide is often sufficient, but several injections may be needed for adequate relief of symptoms. Initial dose: 2.5 mg to 5 mg for smaller joints and 5 mg to 15 mg for larger joints, depending on the specific disease being treated. For adults, doses of up to 10 mg for smaller areas and up to 40 mg for larger areas have usually been sufficient. Single injections into several joints, up to a total of 80 mg, have been given. Administration: For treatment of joints, the usual intra-articular injection technique should be followed. If an excessive amount of synovial fluid is present in the joint, some, but not all, should be aspirated to help relieve pain and to prevent undue dilution of the steroid.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.