Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Detrusin LA is indicated for treating an overactive bladder, with symptoms such as urge urinary incontinence, urgency, and frequency.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Tolterodine works by selectively blocking muscarinic receptors in the bladder wall. Non-clinical studies have shown that its action targets the urinary bladder more strongly than the salivary glands, and it binds muscarinic receptors with high specificity. The body also produces an active breakdown product of tolterodine, the 5-hydroxymethyl metabolite, which works in much the same way as the original drug. In people who metabolise tolterodine rapidly (extensive metabolisers), this metabolite plays a significant role in producing the therapeutic effect. Patients can generally expect to see the benefits of treatment within 4 weeks.

Pregnancy & Breastfeeding

Tolterodine tartrate has not been studied in pregnant women, so it should be used during pregnancy only if the expected benefit to the mother outweighs any possible risk to the unborn baby. It is also not known whether tolterodine passes into breast milk, and for this reason it should not be taken while breastfeeding. Nursing mothers who need this medicine should discuss with their doctor whether to stop breastfeeding or to stop the medicine instead.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Extended-release capsule: The recommended dose is Tolterodine Tartrate 4 mg once daily. Based on individual response and tolerability, the dose may be lowered to 2 mg once daily. For patients with significantly reduced hepatic or renal function, or who are currently taking drugs that are potent inhibitors of CYP3A4, the recommended dose is Tolterodine Tartrate 2 mg daily. Film-coated tablet: The recommended dose is Tolterodine Tartrate 2 mg twice daily, except in patients with impaired liver function or severely impaired renal function (GFR under 30 ml/min), for whom the recommended dose is one Tolterodine Tartrate 1 mg tablet twice daily. If side effects become troublesome, the dose may be reduced from 2 mg to 1 mg twice daily. The effect of treatment should be re-evaluated after 2 to 3 months. Pediatric use: The safety and effectiveness of tolterodine in children have not been established. Geriatric use: No overall differences in safety were observed between older and younger patients treated with Tolterodine.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.