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Terbinafine Hydrochloride

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Indications

Fungal Infection

Terbitac tablet is used to treat onychomycosis of the toenail or fingernail caused by dermatophyte fungi, a condition also known as Tinea Unguium. Terbitac granules are used to treat Tinea Capitis. Terbitac cream is used to treat fungal infections of the skin caused by Trichophyton species (such as T. rubrum, T. mentagrophytes, T. verrucosum and T. violaceum), Microsporum canis and Epidermophyton floccosum. It is also used for yeast infections of the skin, mainly those caused by the genus Candida (such as C. albicans), and for pityriasis (tinea) versicolor caused by Pityrosporum orbiculare, also known as Malassezia furfur. Terbitac 1% Spray is used to treat tinea infections of the skin and is also indicated for pityriasis (tinea) versicolor caused by Malassezia furfur.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Terbinafine is an allylamine antifungal that blocks the biosynthesis of ergosterol, an essential building block of the fungal cell membrane, by inhibiting the enzyme squalene epoxidase. Fungal cells die mainly because squalene builds up to high concentrations and makes the cell membrane abnormally permeable, rather than because of the resulting ergosterol deficiency. Depending on the drug concentration and the fungal species tested in vitro, terbinafine hydrochloride may act as a fungicide, though the clinical relevance of such in vitro findings is not established. Terbinafine has demonstrated activity against most strains of Trichophyton mentagrophytes and Trichophyton rubrum, both in laboratory studies and in actual clinical infections.

Pregnancy & Breastfeeding

Terbinafine tablets have not been thoroughly studied in pregnant women, and although animal reproduction studies do not always predict human outcomes, doctors generally advise waiting until after pregnancy to start this medicine, since treatment for nail fungal infection can safely be delayed. Nursing mothers should also avoid the tablets, since the drug passes into breast milk after it is taken by mouth. With the cream, animal studies of fetal toxicity and fertility have not shown adverse effects, but since no clinical experience exists in pregnant women, it should only be used if the potential benefit clearly outweighs the risk. This form is also excreted in breast milk, so breastfeeding mothers should not apply it during treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Terbinafine tablet: For treating fingernail onychomycosis, the usual dose is Terbinafine 250 mg (one tablet) once daily for 6 weeks. For treating toenail onychomycosis, the usual dose is Terbinafine 250 mg (one tablet) once daily for 12 weeks. The best clinical effect is seen some months after mycological cure and stopping treatment, since this is related to the time needed for a healthy nail to grow out. Terbinafine granules: For body weight under 25 kg, the dose is 125 mg per day for up to 6 weeks. For body weight between 25 and 35 kg, the dose is 187.5 mg per day for up to 6 weeks. For body weight over 35 kg, the dose is 250 mg per day for up to 6 weeks. Terbinafine cream: The cream can be applied once or twice daily. Cleanse and dry the affected areas thoroughly before applying it. Apply the cream to the affected skin and the surrounding area in a thin layer and rub it in lightly. For intertriginous infections (submammary, interdigital, intergluteal, inguinal), the application may be covered with a gauze strip, especially at night. Likely treatment durations are as follows. Tinea corporis and cruris usually need 1 to 2 weeks. Tinea pedis usually needs 1 week. Cutaneous candidiasis usually needs 2 weeks. Pityriasis versicolor usually needs 2 weeks. Relief of clinical symptoms usually occurs within a few days. Irregular use or stopping treatment too early carries a risk of recurrence. If there are no signs of improvement after two weeks, the diagnosis should be verified. Terbinafine 1% Spray: This spray is applied once or twice daily, depending on the indication. The affected areas should be cleansed and dried thoroughly before applying the spray, using enough solution to wet the treatment area or areas thoroughly. For tinea pedis, apply once a day for 1 week. For tinea corporis or cruris, apply once a day for 1 week. For pityriasis versicolor, apply twice a day for 1 week. Relief of clinical symptoms usually occurs within a few days. If there are no signs of improvement after two weeks, the diagnosis should be verified.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.