Indications
Tegazel tablet is used to treat irritable bowel syndrome with constipation (IBS-C) in adult women under 65 years of age.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Tegaserod acts on serotonin type-4 (5-HT4) receptors in the gut, where it stimulates the peristaltic reflex and intestinal secretion, dampens visceral sensitivity, and boosts basal motor activity, helping restore normal motility throughout the gastrointestinal tract. Laboratory binding and functional studies show that, at plasma concentrations seen in clinical use, tegaserod also blocks 5-HT2B receptors in humans, and it is expected to bind only weakly to 5-HT1 receptors. It shows no affinity for 5-HT3 or dopamine receptors, and its main metabolite, M29, has negligible affinity for 5-HT4 receptors in vitro. Animal studies confirmed that tegaserod enhances basal motor activity, normalizes disrupted gut motility, and reduces visceral sensitivity during colorectal distension.
Pregnancy & Breastfeeding
Available data from case reports of tegaserod use during pregnancy have not shown a link to major birth defects, miscarriage, or other adverse outcomes for the mother or baby. It is not known whether tegaserod passes into human breast milk, or what effect it might have on a nursing infant or on milk supply. In rats, tegaserod and its breakdown products do pass into milk, reaching levels much higher than those found in the mother's blood.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.